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Cathinone is not very stable and breaks down to produce cathine and norephedrine.
These chemicals belong to the PPA (phenylpropanolamine) family, a subset of the phenethylamines related to amphetamines and the catecholamines epinephrine and norepinephrine.
The plant usually grows in arid environments, at a temperature range of 5–35 °C (41–95 °F).
However, the attribution was disputed by reports showing the plant extracts from fresh leaves contained another substance more behaviourally active than cathine.
In 1975, the related alkaloid cathinone was isolated, and its absolute configuration was established in 1978.
The effects of oral administration of cathinone occur more rapidly than the effects of amphetamine pills; roughly 15 minutes as compared to 30 minutes in amphetamine. Dilated pupils (mydriasis) are prominent during khat consumption, reflecting the sympathomimetic effects of the drug, which are also reflected in increased heart rate and blood pressure.
Long-term use can precipitate permanent tooth darkening (of a greenish tinge), susceptibility to ulcers, and diminished sex drive.